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A Phase I/II Open-Label, Dose Escalation Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of GSK525762 in Subjects with Relapsed, Refractory Hematologic Malignancies

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In vivo studies using a potassium oxonate/hypoxanthineinduced acute hyperuricemia model showed a significant hyperuricemia effect of compounds 55 , 56, and 58 , consistent with the in vitro inhibition results, but they did not show uric acidreducing activity as good as that of the drug febuxostat [72]